Image analysis Uncovers associations between immune landscape, collagen structure, and neoadjuvant chemotherapy in high-grade serous ovarian carcinomas

This study uses advanced pathomics to quantify changes in immune and collagen architecture in high-grade serous ovarian carcinoma following neoadjuvant chemotherapy (NACT). Significant increases in tumor-infiltrating lymphocyte (TIL) density (p = 0.01754) and changes in collagen fiber orientation (mean entropy p = 0.00254) post-NACT were observed, correlating strongly with overall survival outcomes. 

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